Wednesday, July 29, 2020

It Takes a Pandemic to Raise a Child

https://www.nytimes.com/2020/07/24/nyregion/climate-change-nyc.html
This is a NYT article about the effect of increased temperatures in the metro area on the number of new species. NYC, once classified as a humid subtropical climate, has achieved the distinction of residing in the humid continental category, summers averaging above 72 degrees F and winters above 27, on average. Forget about wrapping your fruit trees in burlap in the winter, for example, not that I have ever done this. Enjoy one of the 15 sultry tropical nights every summer when temperatures stay above 75: it used to be 10. The article doesn't suggest growing palmetto palms in Central Park: Georgia, Florida and South Carolina still retain that distinction. The downside is that invasive weeds, such as knotweed and porcelain berry are running rampant. In the fauna department, bugs that died off in the winter are surviving and multiplying, such as the hemlock woolly adelgid.












https://www.sciencemag.org/news/2020/07/scientists-pull-living-microbes-100-million-years-beneath-sea
Here is a Science magazine article, which I would subtitle, "So you think you have sleep issues?"
It describes 100 million year old microbes which, when brought back to the lab, revived and multiplied. A geomicrobiologist at the Japan Institute for Marine Earth Science and Technology launched a drilling expedition at a site in Australia, at a confluence of ocean currents that is considered the deadest part of the world's oceans. They extracted samples from the mud cores and fed them with nitrogen and carbon compounds. There were 100x fewer samples than in ordinary sea mud and they had to develop special techniques to analyze the small numbers of cells. In terms of geological time, this is very impressive.








https://www.nytimes.com/2020/07/28/health/alzheimers-blood-test.html A NYT article to remind people that non-Covid research continues. although there might be some advantage to our forgetting at least the first half of 2020. Looking for diagnostic tests for AD has been proceeding apace for years. This is a great result. The test can distinguish whether people with dementia had Alzheimer’s instead of another condition. And can identify signs of the degenerative, deadly disease 20 years before memory and thinking problems are expected in people with a genetic mutation that causes Alzheimer’s. The test is inexpensive and should be available in 2-3 years. This research was published in JAMA.

Wednesday, July 8, 2020

Black Deaths Matter

https://www.nytimes.com/2020/07/02/health/santillana-coronavirus-model-forecast.html
This is a NYT article about using social media to predict outbreaks. An international team of scientists has developed an algorithm that could be predictive and get a two0week head start from Twitter, Google searches and mobility data from smartphones that would guide whether to relax or ramp up public health interventions. This is from a prepub from arXiv.org and the commentary is by the director of Machine Intelligence Lab at Boston Children's Hospital. With the caveat that the Google Flu Trends Algorithm from 2008 didn't work as expected but researchers have made adjustments to the program combining Google searches with other kinds of data. It is called a "harmonized" algorithm because it weights the data sources depending on how strongly it correlated to a coming increase in cases.









https://www.nytimes.com/2020/07/02/opinion/coronavirus-jail.html
This is a commentary from an anthropology  Ph.D. candidate and medical student about the increase in the number of Covid-19 cases in jails. His research deals with the Cook County (Chicago) jails and was published in the Journal of Health Affairs (not a premier journal from the sound of the title). The study showed that "the cycle of arrests, jailings and releases was the most significant predictor of the spread of the coronavirus in Chicago and the rest of Illinois." A sixth of all of the cases in the city and state were linked to people who jailed and released from a single prison, according to data through April 19th. Nonviolent offenses account for 95% of the more than 10 million arrests in America every year. The conclusion from this data is that standard policing and incarceration policies are driving preventable spread of the virus. People are being released from prison daily with the belief they are negative  when in reality the virus has begun to spread in their bodies.  The authors suggest that policymakers should stop the daily cycling of thousands of people in and out of jails. During the pandemic issues of criminal justice reform should not be determined by partisan politics.












https://www.nytimes.com/2020/06/30/upshot/coronavirus-economists-dexamethasone.html
This is the Upshot and a discussion of the Recovery trial, a randomized controlled trial in Britain. It showed that natural experiments, such as when a shortage of one particular drug that was used to treat sepsis gave scientists the unique ability to assess the effects of the drug on mortality rates. Apparently, natural experiments allow a more causal interpretation of data, while associational studies, typical in medicine, do not.  This points out the sometimes-abritary clinical cutoffs made to allocate particular treatments. For example, a hospital decides whether to provide a ventilator to patients based on whether they use 6 liters of oxygen per minute, but actually a 5-liter-per minute patient is pretty much the same. The commentary suggests that these questions must be asked and  thresholds must be known and interrogated. Differences in treatment around the threshold must be examined to see whether they correspond to differences in clinical outcomes. In terms of the Recovery trial, after the results were announced, the data for critically ill Covid-19 patients were examined, with the expectation that patients hospitalized before the Recovery trail results were announced would fare worse than those hospitalized in the days afterward, assuming that doctors started using DEXA.









https://www.nytimes.com/2020/07/14/us/politics/trump-cdc-coronavirus.html
Article in NYT detailing the  protracted rape of the CDC by the administration. So the HHS is now being tasked with collecting daily reports about the patients that each hospital is treating, number of available beds/ventilators, and other information vital to tracking the pandemic. S'posed to make it easier for decisions about allocating short-supply items like remdesivir, but in all likelihood this new policy will make it hard to access new information not open to the public, potentially affecting the work of scores of researchers, modelers and health officials who rely on data formerly sent to the CDC to make projections and crucial decisions. Just another "trump" in the road. Will this also be true of the Weather Bureau, the US Geological Service, NASA, FDA? Will the federal government be hiring new data "remodelers" trained to suppress information? What will be their civil service grades?
 








https://www.statnews.com/2020/07/16/hospital-data-reporting-covid-19/

This is from StatNews about an alarming new change in the way real-time Covid-19 data is reported. Accurate and timely reporting of data informs stop-on-a-dime policy changes. Covid-19 data,rather than being reported to CDC and HHS is now only being reported to the HHS, leading to concerns that the data would be eliminated, manipulated, falsified or all three. The rationale is data consolidation in order to make decisions about allocation of scarce resources, such as remdesivir.  “In the midst of the worst public health crisis in a century, it is counter-productive to create a new mechanism which will be extremely complicated to build and implement,” public health officials, including former CDC director Tom Frieden, wrote.  The data is openly available on the CDC’s website and allows some of the most consulted Covid-19 tracking sites, like covidexitstrategy.org, to provide numbers on how many hospital beds hospitals are open in different states.


Thursday, July 2, 2020

Real men wear masks

https://science.sciencemag.org/content/368/6498/1414
This is a science mag article about our favorite whipping boy and my former employer, ETS.  As bad luck would have it, just when unis are thinking of not requiring the GREs, along comes Covid-19, requiring tests to be administered online. According to Science, the specifications for students who take the online GREs include being alone in a room, having a computer with a webcam, having a whiteboard if they take notes, sitting in a standard, not overstuffed chair, and ensuring no one will enter the room for the entire 3 hours. How hard/easy is this? I read about a school that had to set up a hotspot in a school bus so the profs could get the internet for teaching. We are talking about high school students here. For schools that had been considering disconnecting from the GRE as a requirement for graduate school. Covid-19 may be the camel's-back-breaker. Good riddance to high stakes testing. There is proctoring software (examsoft) that universities make available for giving exams but probably also a readily available-to-students industry for getting around it.