http://www.nytimes.com/2016/12/12/upshot/the-power-of-simple-life-changes-to-prevent-heart-disease.html This was a column in the NYT (Science Times) reporting on a study published in NEJM about lifestyle changes and how they are effective against heart disease even if you have a significant number of risk factors working against you. It is a summary of four studies. A risk score was generated using SNPs (Single Nucleotide Polymorphisms) which might predispose an individual to get heart disease. Researchers used some simple lifestyle changes and examined what the effects were on the actual incidences of coronary events. The result showed that lifestyle changes were even effective in those individuals deemed to be at high risk for a cardiovascular event.
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